Source: | Rabbit | Gene Id: | 55240 |
Isotype: | IgG | Swiss Prot: | Q658P3 |
purity: | Affinity purification |
Background: |
STEAP3 a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IF ICC |
Clonality | Polyclonal Antibody |
Calculated MW | 54 kDa |
Recommended Dilutions |
WB 1:500-1:1000
IF 1:100-1:500
ICC 1:100-1:500
|
Immunogen | A synthetic peptide |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | Metalloreductase STEAP3, EC 1.16.1.-, Six-transmembrane epithelial antigen of prostate 3, Tumor suppressor-activated pathway protein 6, hTSAP6, pHyde, hpHyde, Dudulin-2, STEAP3, TSAP6 |
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