| No | Size | Price | Availability | |
| ARP11214-61 | 50ul | 1500.00 | In Stock |  |
| ARP11214-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 11214 |
| Isotype: | IgG | Swiss Prot: | Q12802 |
| purity: | Affinity purification |
| Background: |
| The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins. [provided by RefSeq |
| Reactivity | Human |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 307 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AKAP 13, Protein kinase A-anchoring protein 13, Breast cancer nuclear receptor-binding auxiliary protein, Human thyroid-anchoring protein 31, Guanine nucleotide exchange factor Lbc, AKAP-Lbc, LBC oncogeneP47, Lymphoid blast crisis oncogene, Non-oncogenic |
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