CHN 1/Alpha-chimerin Rabbit Polyclonal Antibody
No Size Price Availability  
YRP11544-01 50ul 1500.00 In Stock
YRP11544-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id:
Isotype: IgG Swiss Prot:
purity: Purified by Protein A.
Background:
The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol). Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW /
Recommended Dilutions
WB 1:100-1:1000
IHC 1:100-1:500
IF 1:50-1:200
Immunogen KLH conjugated synthetic peptide derived from human Alpha-chimerin
Storage Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20℃ for 12 months
Synonym A-chimaerin, Alpha-chimerin, ARHGAP2, CHIN_HUMAN, CHN, Chn1, N chimaerin, N chimerin, N-chimaerin, N-chimerin, NC, Rho GTPase-activating protein 2, RHOGAP2.
This product is for research use only, not for diagnostic or therapeutic use!

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