| No | Size | Price | Availability | |
| ARP9495-61 | 50ul | 1500.00 | In Stock |  |
| ARP9495-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 9495 |
| Isotype: | IgG | Swiss Prot: | P24588 |
| purity: | Affinity purification |
| Background: |
| The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq |
| Reactivity | Human |
| Tested applications | WB IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 47 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | A-kinase anchor protein 5, A-kinase anchor protein 79 kDa, AKAP 79, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein, H21, AKAP5, AKAP79 |
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