| No | Size | Price | Availability | |
| ARP6929-61 | 50ul | 1500.00 | In Stock |  |
| ARP6929-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6929 |
| Isotype: | IgG | Swiss Prot: | P15923 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 68 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | E12, ITF1, Immunoglobulin enhancer binding factor E12/E47, Immunoglobulin transcription factor-1, Kappa-E2-binding factor, TCF-3, TCF3, TFE2, Transcription factor E2-alpha, Transcription factor ITF-1, Transcription factor-3 |
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