| No | Size | Price | Availability | |
| ARP8412-62 | 50ul | 1500.00 | In Stock |  |
| ARP8412-62 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8412 |
| Isotype: | IgG | Swiss Prot: | O75815 |
| purity: | Affinity purification |
| Background: |
| a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described. |
| Reactivity | Human |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 92 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SH2-containing protein Nsp2, breast cancer antiestrogen resistance 3 |
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