Source: | Rabbit | Gene Id: | 3309 |
Isotype: | IgG | Swiss Prot: | P11021 |
purity: | Affinity purification |
Background: |
GRP78 a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells.. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | 78 kDa |
Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:100-1:500
|
Immunogen | A synthetic peptide derived from human GRP78 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | BIP, GLUCOSE-REGULATED PROTEIN 78-KD, HEAT-SHOCK 70-KD PROTEIN 5, IMMUNOGLOBULIN HEAVY CHAIN-BINDING PROTEIN, heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
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