Source: | Rabbit | Gene Id: | 389421 |
Isotype: | IgG | Swiss Prot: | Q6ZN17 |
purity: | Affinity purification |
Background: |
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. |
Reactivity | Human |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 27 kDa |
Recommended Dilutions |
WB 1:500-1:1000
|
Immunogen | Peptide sequence around aa.242~246( P-S-V-Q-K) derived from Human LIN28B |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | CSDD2, FLJ16517 |
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