
| Source: | Rabbit | Gene Id: | 79923 |
| Isotype: | IgG | Swiss Prot: | Q9H9S0 |
| purity: | Affinity purification |
| Background: |
| Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes By similarity. Acts as a transcriptional activator or repressor By similarity. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' By similarity. When overexpressed, promotes cells to enter into S phase and proliferation |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 42 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | Peptide sequence around aa.137~141 (K-Q-V-K-T) derived from Nano g |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Homeobox transcription factor Nanog |
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