| No | Size | Price | Availability | |
| ARP7291-61 | 50ul | 1500.00 | In Stock |  |
| ARP7291-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7291 |
| Isotype: | IgG | Swiss Prot: | Q15672 |
| purity: | Affinity purification |
| Background: |
| Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 29 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | Peptide sequence around aa.18~22(S-N-S-E-E) derived from Human Twist1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | SCS, ACS3, CRS1, BPES2, BPES3 |
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