| No | Size | Price | Availability | |
| ARP5335P-61 | 50ul | 1500.00 | In Stock |  |
| ARP5335P-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5335 |
| Isotype: | IgG | Swiss Prot: | P19174 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 155 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human PLCG1 around the phosphorylation site of Tyrosine 771 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, EC 3.1.4.11, PLC-148, PLC-II, PLC-gamma1, PLC1, PLCG-1, Phospholipase C-gamma-1 |
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