Source: | Rabbit | Gene Id: | 6885 |
Isotype: | IgG | Swiss Prot: | O43318 |
purity: | Affinity purification |
Background: |
AK1 a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. |
Reactivity | Human, Mouse, Rat |
Tested applications | WB |
Clonality | Polyclonal Antibody |
Calculated MW | 60 kDa |
Recommended Dilutions |
WB 1:500-1:2000
|
Immunogen | A synthetic peptide derived from human MAP3K7 around the phosphorylation site of Threonine 187 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | EC 2.7.11.25, M3K7, MAP3K7, Mitogen-activated protein kinase kinase kinase 7, TGF-beta- activated kinase 1, Transforming growth factor-beta-activated kinase 1, kinase TAK1 |
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