| No | Size | Price | Availability | |
| ARP5504-61 | 50ul | 1500.00 | In Stock |  |
| ARP5504-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5504 |
| Isotype: | IgG | Swiss Prot: | P41236 |
| purity: | Affinity purification |
| Background: |
| PPP1R2 a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 25 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human PPP1R2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | I-2, IPP-2, IPP2, Protein phosphatase inhibitor 2 |
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