| No | Size | Price | Availability | |
| ARP79930-61 | 50ul | 1500.00 | In Stock |  |
| ARP79930-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 79930 |
| Isotype: | IgG | Swiss Prot: | Q7L591 |
| purity: | Affinity purification |
| Background: |
| Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP. May modulate Abl function. On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP. 4 isoforms of the human protein are produced by alternative splicing. |
| Reactivity | Human, Mouse |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 58 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A synthetic peptide derived from human DOK3 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Docking protein 3, Downstream of tyrosine kinase 3, DOK3 |
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