| No | Size | Price | Availability | |
| ARP10614-61 | 50ul | 1500.00 | In Stock |  |
| ARP10614-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 10614 |
| Isotype: | IgG | Swiss Prot: | O94992 |
| purity: | Affinity purification |
| Background: |
| HEXIM1 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 40 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human HEXIM1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Cardiac lineage protein 1, CLP1, EDG1, Estrogen down-regulated gene 1 protein, FLJ13562, hexamethylene bis-acetamide inducible 1, Hexamethylene bis-acetamide-inducible protein 1, hexamethylene bisacetamide-inducible protein, hexamethylene-bis-acetamide-in |
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