| No | Size | Price | Availability | |
| ARP6502-61 | 50ul | 1500.00 | In Stock |  |
| ARP6502-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 6502 |
| Isotype: | IgG | Swiss Prot: | Q13309 |
| purity: | Affinity purification |
| Background: |
| SKP2 an F-box protein of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin ligase system. The F-box component of the SCF complex is responsible for recognizing different substrates for ubiquitination. The SCF E3 complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Three alternatively-spliced isoforms have been described. |
| Reactivity | Human |
| Tested applications | WB IHC IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 47 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human SKP2/p45 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CDK2/cyclin A-associated protein p45, cyclin A/CDK2-associated protein p45, Cyclin-A/CDK2-associated protein p45, F-box protein Skp2, F-box/LRR-repeat protein 1, FBL1, FBXL1, FLB1, MGC1366, p45skp2, S-phase kinase-associated protein 2, S-phase kinase-ass |
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