| No | Size | Price | Availability | |
| ARP11144-61 | 50ul | 1500.00 | In Stock |  |
| ARP11144-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 11144 |
| Isotype: | IgG | Swiss Prot: | Q14565 |
| purity: | Affinity chromatography |
| Background: |
| BARD1 the BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. Colocalizes with BRCA1 into discrete subnuclear foci during S phase. Can translocate to the cytoplasm. |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 86 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
|
| Immunogen | A synthetic peptide derived from human BARD1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | BARD-1, BARD1, BRCA1 associated RING domain 1, BRCA1-associated RING domain gene 1, BRCA1-associated RING domain protein 1 |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
