Source: | Rabbit | Gene Id: | 9575 |
Isotype: | IgG | Swiss Prot: | O15516 |
purity: | Affinity chromatography |
Background: |
CLOCK ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4. |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC |
Clonality | Polyclonal Antibody |
Calculated MW | 95 kDa |
Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
Immunogen | A synthetic peptide derived from human Clock |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | BHLHE8, circadian locomoter output cycles kaput protein, Circadian locomoter output cycles protein kaput, Class E basic helix-loop-helix protein 8, CLOCK, clock homolog (mouse), hCLOCK, KAT13D, KIAA0334 |
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