Source: | Rabbit | Gene Id: | 23037 |
Isotype: | IgG | Swiss Prot: | O15018 |
purity: | Affinity purification |
Background: |
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. Two transcript variants encoding different isoforms have been found for this gene. |
Reactivity | Human, Mouse, Rat |
Tested applications | IHC IF ICC |
Clonality | Polyclonal Antibody |
Calculated MW | 301 kDa |
Recommended Dilutions |
IHC 1:50-1:200
IF 1:100-1:500
ICC 1:100-1:500
|
Immunogen | A synthetic peptide derived from human PDZD2 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | PDZ domain-containing protein 2, PDZ domain-containing protein 3, Activated in prostate cancer protein, Processed PDZ domain-containing protein 2, PDZD2, AIPC, KIAA0300, PDZK3 |
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