| No | Size | Price | Availability | |
| ARP7132-61 | 50ul | 1500.00 | In Stock |  |
| ARP7132-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 7132 |
| Isotype: | IgG | Swiss Prot: | P19438 |
| purity: | Affinity purification |
| Background: |
| TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 50 kDa |
| Recommended Dilutions |
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human TNFR1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CD120a, FPF, MGC19588, p55, p55-R, p60, TBP1, TBPI, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-RI, TNFAR, TNFR-I, TNFR1, TNFR55, TNFR60, TNFRSF1A, TNR1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor |
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