Source: | Rabbit | Gene Id: | 9611 |
Isotype: | IgG | Swiss Prot: | O75376 |
purity: | Affinity chromatography |
Background: |
N-CoR1 is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. |
Reactivity | Human, Mouse |
Tested applications | WB IHC |
Clonality | Polyclonal Antibody |
Calculated MW | 270 kDa |
Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
Immunogen | A synthetic peptide derived from human NCoR1 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | hCIT529I10, hN-CoR, KIAA1047, MGC104216, N-CoR, N-CoR1, NCOR1, nuclear receptor co-repressor 1, Nuclear receptor corepressor 1, thyroid hormone- and retinoic acid receptor-associated corepressor 1, TRAC1 |
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