Source: | Rabbit | Gene Id: | 140885 |
Isotype: | IgG | Swiss Prot: | P78324 |
purity: | Affinity chromatography |
Background: |
SHPS1 Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. |
Reactivity | Human, Mouse, Rat |
Tested applications | WB IHC |
Clonality | Polyclonal Antibody |
Calculated MW | 55 kDa |
Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
Immunogen | A synthetic peptide derived from human SHPS1 |
Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Synonym | BIT, Brain Ig-like molecule with tyrosine-based activation motifs, brain-immunoglobulin-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172A, Inhibitory receptor SHPS-1, Macrophage fusion receptor, MFR, MYD-1, M |
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