| No | Size | Price | Availability | |
| ARP5071-61 | 50ul | 1500.00 | In Stock |  |
| ARP5071-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5071 |
| Isotype: | IgG | Swiss Prot: | O60260 |
| purity: | Affinity chromatography |
| Background: |
| PARK2 Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include SYT11, CCNE1, GPR37, STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP, SEPT5 and AIMP2. May play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of PARK2. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 52 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human Parkin |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | AR-JP, E3 ubiquitin ligase, E3 ubiquitin-protein ligase parkin, LPRS2, PARK2, parkin, parkin 2, Parkinson disease (autosomal recessive, juvenile) 2, parkin, Parkinson disease protein 2, Parkinson juvenile disease protein 2, PDJ, PRKN, PRKN2 |
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