| No | Size | Price | Availability | |
| ARP8533-61 | 50ul | 1500.00 | In Stock |  |
| ARP8533-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8533 |
| Isotype: | IgG | Swiss Prot: | Q9UNS2 |
| purity: | Affinity chromatography |
| Background: |
| COPS3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 47 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human COPS3 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | COP9 complex subunit 3, COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis), COP9 signalosome complex subunit 3, COPS3, CSN3, JAB1-containing signalosome subunit 3, SGN3, Signalosome subunit 3 |
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