| No | Size | Price | Availability | |
| ARP2550-61 | 50ul | 1500.00 | In Stock |  |
| ARP2550-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 2550 |
| Isotype: | IgG | Swiss Prot: | Q9UBS5 |
| purity: | Affinity chromatography |
| Background: |
| GABBR1 Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 110 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human GABBR1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | dJ271M21.1.1, dJ271M21.1.2, FLJ92613, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABAB, subunit 1c, GABABR1, GABBR1, GABBR1-3, GABR1, gamma-aminobutyric acid (GABA) B receptor 1, gamma-aminobutyric acid (GABA) B receptor, 1, Gamma-aminobutyric acid type B re |
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