| No | Size | Price | Availability | |
| ARP8453-61 | 50ul | 1500.00 | In Stock |  |
| ARP8453-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 8453 |
| Isotype: | IgG | Swiss Prot: | Q13617 |
| purity: | Affinity chromatography |
| Background: |
| CUL2 Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 82,84 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human Cullin 2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CUL-2, CUL2, cullin 2, Cullin-2, MGC131970 |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
