| No | Size | Price | Availability | |
| ARP200558-61 | 50ul | 1500.00 | In Stock |  |
| ARP200558-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 200558 |
| Isotype: | IgG | Swiss Prot: | Q8IW19 |
| purity: | Affinity chromatography |
| Background: |
| APLF Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Belongs to the APLF family. Interacts with LIG4, PARP1, XRCC1, XRCC4 and XRCC5. |
| Reactivity | Human, Mouse |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 57 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IHC 1:50-1:200
|
| Immunogen | A synthetic peptide derived from human APLF |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | APFL, APLF, Aprataxin and PNK-like factor, aprataxin and PNKP like factor, aprataxin- and PNK-like factor, Apurinic-apyrimidinic endonuclease APLF, C2orf13, FLJ16593, MGC47799, PALF, PNK and APTX-like FHA domain-containing protein, PNK and APTX-like FHA p |
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