| No | Size | Price | Availability | |
| ARP581-61 | 50ul | 1500.00 | In Stock |  |
| ARP581-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 581 |
| Isotype: | IgG | Swiss Prot: | Q07812 |
| purity: | Affinity chromatography |
| Background: |
| Bax Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis. Belongs to the Bcl-2 family. Homodimer. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). 8 isoforms of the human protein are produced by alternative splicing. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF ICC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 21 kDa |
| Recommended Dilutions |
WB 1:500-1:3000
IF 1:100-1:500
ICC 1:100-1:500
|
| Immunogen | A synthetic peptide derived from human Bax |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | Apoptosis regulator BAX, BAX, Bcl-2-like protein 4, BCL2-associated X protein, Bcl2-L-4, BCL2L4 |
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