| No | Size | Price | Availability | |
| ARP672P-61 | 50ul | 1500.00 | In Stock |  |
| ARP672P-61 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 672 |
| Isotype: | IgG | Swiss Prot: | P38398 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. |
| Reactivity | Human |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 220 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A synthetic peptide derived from human BRCA1 around the phosphorylation site of Sersine 1457 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | BRCA1, Breast cancer type 1 susceptibility protein, familial breast/ovarian cancer gene 1 |
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