| No | Size | Price | Availability | |
| ARP5170P-01 | 50ul | 1500.00 | In Stock |  |
| ARP5170P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 5170 |
| Isotype: | IgG | Swiss Prot: | O15530 |
| purity: | Affinity purification |
| Background: |
| The μ-opioid receptor (MOR) belongs to the superfamily of G-protein-coupled receptors. MOR mediates the analgesic and rewarding effects of morphine and other opiates as well as the actions of several endogenous opioid peptides. Upon binding to its ligands, this Gi-coupled receptor inactivates adenylyl cyclase and activates a variety of G-beta-gamma-dependent pathways including the MAPK and the PI3K/Akt cascades. Trafficking of these receptors to and from the plasma membrane and their desensitization play a significant role in morphine tolerance. As with other GPCRs, these processes are modulated by phosphorylation at diverse sites within intracellular domains. Among other sites, agonist-specific phosphorylation of serine 375 in mouse (serine 377 in human) MOR is essential for its internalization. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 63 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:100
IF 1:100-1:200
|
| Immunogen | A phospho specific peptide corresponding to residues surrounding S241 of human PDPK1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | PDK1, PDPK2, PRO0461 |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
