| No | Size | Price | Availability | |
| ARP4193P-01 | 50ul | 1500.00 | In Stock |  |
| ARP4193P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 4193 |
| Isotype: | IgG | Swiss Prot: | Q00987 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 55 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:100
|
| Immunogen | A phospho specific peptide corresponding to residues surrounding S166 of human MDM2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | HDMX, hdm2, ACTFS |
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