| No | Size | Price | Availability | |
| ARP1978P-01 | 50ul | 1500.00 | In Stock |  |
| ARP1978P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1978 |
| Isotype: | IgG | Swiss Prot: | Q13541 |
| purity: | Affinity purification |
| Background: |
| Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity. Multiple 4E-BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | / |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A phospho specific peptide corresponding to residues surrounding S65 of human EIF4EBP1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | 4E-BP1, 4EBP1, BP-1, MGC4316, PHAS-I |
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