| No | Size | Price | Availability | |
| ARP1111P-01 | 50ul | 1500.00 | In Stock |  |
| ARP1111P-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1111 |
| Isotype: | IgG | Swiss Prot: | O14757 |
| purity: | Affinity purification |
| Background: |
| The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 54 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
|
| Immunogen | A phospho specific peptide corresponding to residues surrounding S280 of human CHEK1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | CHK1 |
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