PSMB8 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP5696-01 50ul 1500.00 In Stock
ARP5696-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5696
Isotype: IgG Swiss Prot: P28062
purity: Affinity purification
Background:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
Reactivity Human
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 30kDa
Recommended Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Immunogen A recombinant protein of human PSMB8
Storage Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym JMP, ALDD, LMP7, NKJO, D6S216, PSMB5i, RING10, D6S216E
This product is for research use only, not for diagnostic or therapeutic use!

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