Source: | Rabbit | Gene Id: | 54820 |
Isotype: | IgG | Swiss Prot: | Q9NXR1 |
purity: | Affinity purification |
Background: |
This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. |
Reactivity | Human, Mouse |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | 39kDa |
Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:100
|
Immunogen | A recombinant protein of human NDE1 |
Storage | Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | NDE, LIS4, MHAC, NUDE, NUDE1, HOM-TES-87 |
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