NPHP1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP4867-01 50ul 1500.00 In Stock
ARP4867-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4867
Isotype: IgG Swiss Prot: O15259
purity: Affinity purification
Background:
This gene encodes a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 83kDa
Recommended Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50- 1:100
Immunogen A recombinant protein of human NPHP1
Storage Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym NPH1, JBTS4, SLSN1
This product is for research use only, not for diagnostic or therapeutic use!

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