COCH Rabbit Polyclonal Antibody
No Size Price Availability  
ARP1690-01 50ul 1500.00 In Stock
ARP1690-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 1690
Isotype: IgG Swiss Prot: O43405
purity: Affinity purification
Background:
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Reactivity Human, Mouse
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 59kDa
Recommended Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50- 1:100
Immunogen A recombinant protein of human COCH
Storage Store at -20oC (regular) or -80oC (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym DFNA9, COCH5B2, COCH-5B2
This product is for research use only, not for diagnostic or therapeutic use!

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