| No | Size | Price | Availability | |
| ARP1729-02 | 50ul | 1500.00 | In Stock |  |
| ARP1729-02 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1729 |
| Isotype: | IgG | Swiss Prot: | O60610 |
| purity: | Affinity purification |
| Background: |
| Formins are a family of large multidomain actin nucleation/polymerization proteins characterized by their catalytic FH2 domains. The mammalian diaphanous-related formin (mDia/diap) subfamily, including mDia1/diap1, mDia2/diap3 and mDia3/diap2, are effectors of Rho family small GTPases. In response to Rho, mDia/diap proteins are involved in the regulation of multiple cell functions including cytoskeletal dynamics, migration, adhesion, polarity and cell shape. mDia1/diap1 is activated by GTP-bound Rho, leading to Rho-associated kinase (ROCK)-dependent stress fiber formation. Rho activation of mDia1 has also been shown to regulate serum response factor (SRF)-dependent transcription, and has been implicated in human cancer phenotypes such as ras-mediated transformation, metastasis and invasion. mDia3/diap2, activated by the Rho family small GTPase cdc42, regulates the attachment of microtubules to the kinetochore during mitosis in mammalian cells. Rho-dependent activation of mDia2/diap3 is important in assembly of the contractile ring during cytokinesis. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 141 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IHC 1:50-1:200
|
| Immunogen | A recombinant protein of human DIAPH1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DIA1, DRF1, DFNA1, LFHL1, hDIA1 |
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