GRN Rabbit Polyclonal Antibody
No Size Price Availability  
ARP2896-01 50ul 1500.00 In Stock
ARP2896-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 2896
Isotype: IgG Swiss Prot: P28799
purity: Affinity purification
Background:
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Reactivity Human, Mouse
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 63kDa
Recommended Dilutions
WB 1:500 - 1:2000
IHC 1:50 - 1:200
Immunogen A recombinant protein of human GRN
Storage Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonym GEP, GP88, PEPI, PGRN, CLN11, PCDGF
This product is for research use only, not for diagnostic or therapeutic use!

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