SMAD4 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP4089-01 50ul 1500.00 In Stock
ARP4089-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 4089
Isotype: IgG Swiss Prot: Q13485
purity: Affinity purification
Background:
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 60 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
Immunogen A recombinant protein of human SMAD4
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym JIP, DPC4, MADH4, MYHRS
This product is for research use only, not for diagnostic or therapeutic use!

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