CTNNA1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP1495-01 50ul 1500.00 In Stock
ARP1495-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 1495
Isotype: IgG Swiss Prot: P35221
purity: Affinity purification
Background:
Adherens junctions are dynamic structures that form cell-cell contacts and are important in development, differentiation, tissue integrity, morphology and cell polarity. They are composed of the transmembrane proteins, cadherins, which bind cadherins on adjacent cells in a calcium-dependent manner. On the cytoplasmic side of adherens junctions, the classic model states that cadherins are linked to the cytoskeleton through β- and α-catenin. α-E-catenin is ubiquitously expressed, α-N-catenin is expressed in neuronal tissue, and α-T-catenin is primarily expressed in heart tissue. Research studies have demonstrated that loss of E-cadherin and α-E-catenin occurs during the progression of several human cancers, indicating that the breakdown of adherens junctions is important in cancer progression. Research studies also suggest that, rather than acting as a static link between cadherins and actin, α-catenin regulates actin dynamics directly, possibly by competing with the actin nucleating arp2/3 complex. α-catenin also plays a role in regulating β-catenin-dependent transcriptional activity, affecting differentiation and response to Wnt signaling. α-catenin binds to β-catenin in the nucleus, preventing it from regulating transcription, and levels of both proteins appear to be regulated via proteasome-dependent degradation.
Reactivity Human, Mouse, Rat
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 100 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
Immunogen A recombinant protein of human CTNNA1
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym CAP102
This product is for research use only, not for diagnostic or therapeutic use!

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