| No | Size | Price | Availability | |
| ARP3716-01 | 50ul | 1500.00 | In Stock |  |
| ARP3716-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 3716 |
| Isotype: | IgG | Swiss Prot: | P23458 |
| purity: | Affinity purification |
| Background: |
| Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC |
| Clonality | Polyclonal Antibody |
| Calculated MW | 130 kDa |
| Recommended Dilutions |
WB 1:500-1:1000
IHC 1:50-1:100
|
| Immunogen | A synthetic peptide of human JAK1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | JTK3, JAK1A, JAK1B |
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