TPT1 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP7178-01 50ul 1500.00 In Stock
ARP7178-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 7178
Isotype: IgG Swiss Prot: P13693
purity: Affinity purification
Background:
Translationally controlled tumor protein (TCTP/p23/HRF) is a ubiquitously expressed and highly conserved protein involved in various cellular processes, such as its role as a histamine releasing factor in chronic allergic disease. TCTP binds tubulin in a cell cycle dependent manner and is associated with the mitotic spindle. In addition, TCTP interacts with the actin cytoskeleton to regulate cell shape. In mitosis, TCTP is phosphorylated by PLK at Ser46, decreasing microtubule stability. TCTP interacts with the small GTPase Rheb, possibly acting as a GEF, thereby activating the TORC1 pathway and controlling cell growth and proliferation. TCTP has also been shown to be involved in apoptosis and cell stress. In cultured cells, reduction in TCTP expression can cause loss of the malignant phenotype.
Reactivity Human, Mouse, Rat
Tested applications WB IHC IF
Clonality Polyclonal Antibody
Calculated MW 20 kDa
Recommended Dilutions
WB 1:500-1:2000
IHC 1:50-1:200
IF 1:50-1:200
Immunogen A recombinant protein of human TPT1
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym HRF, p02, p23, TCTP
This product is for research use only, not for diagnostic or therapeutic use!

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