Source: | Rabbit | Gene Id: | 5199 |
Isotype: | IgG | Swiss Prot: | P27918 |
purity: | Affinity purification |
Background: |
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Reactivity | Human, Mouse, Rat, |
Tested applications | WB IHC IF |
Clonality | Polyclonal Antibody |
Calculated MW | 51kDa |
Recommended Dilutions |
WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:50- 1:200
|
Immunogen | A recombinant protein of human CFP |
Storage | Store at -20oC or -80oC. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Synonym | BFD, PFC, PFD, PROPERDIN |
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