| No | Size | Price | Availability | |
| ARP55677-01 | 50ul | 1500.00 | In Stock |  |
| ARP55677-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 55677 |
| Isotype: | IgG | Swiss Prot: | Q96ST2 |
| purity: | Affinity purification |
| Background: |
| Various steps in gene expression, such as mRNA processing, surveillance, export, and synthesis are coupled to transcription elongation. The C-terminal domain (CTD) of the large subunit of RNA polymerase II plays an important role in the integration of these different steps. IWS1 interacts with Spt6, a CTD-binding transcription elongation factor and H3 chaperone. IWS1 also recruits another CTD-binding protein, HYPB/Setd2 histone methyltransferase, to the RNA polymerase II complex for elongation-coupled H3K36 trimethylation. Thus, IWS1 links Spt6 and HYPB/Setd2 in a large complex and regulates mRNA synthesis and histone methylation at the co-transcriptional level. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 92 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human IWS1 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DKFZp761G0123, FLJ10006, FLJ14655, FLJ32319, MGC126375, MGC126376 |
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