| No | Size | Price | Availability | |
| ARP22974-01 | 50ul | 1500.00 | In Stock |  |
| ARP22974-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 22974 |
| Isotype: | IgG | Swiss Prot: | Q9ULW0 |
| purity: | Affinity purification |
| Background: |
| The Ras family small GTPase Ran is involved in nuclear envelope formation, assembly of the mitotic spindle, and nuclear transport. TPX2, a target of active Ran (RanGTP), is a microtubule nucleating protein. TPX2 is inactive when bound to nuclear importin-alpha. RanGTP activity disrupts this interaction, relieving inhibition of TPX2. TPX2 binding activates Aurora A kinase and promotes its localization to the mitotic spindle. DNA damage in mitosis leads to loss of interaction between Aurora A and TPX2 and inactivation of Aurora A kinase. TPX2 is highly expressed in pancreatic cancer cells, and knockdown of TPX2 expression in these cells is associated with increased sensitivity to paclitaxel. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 86 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IF 1:50-1:100
|
| Immunogen | A recombinant protein of human TPX2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DIL2, p100, DIL-2, HCTP4, FLS353, HCA519, REPP86, C20orf1, C20orf2, GD:C20orf1 |
沪ICP备15003525号-1 Copyright ©, 2013-2022, Yihyson All Rights Reserved.
