PIK3C3 Rabbit Polyclonal Antibody
No Size Price Availability  
ARP5289-01 50ul 1500.00 In Stock
ARP5289-01 100ul 2000.00 In Stock
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Source: Rabbit Gene Id: 5289
Isotype: IgG Swiss Prot: Q8NEB9
purity: Affinity purification
Background:
Three distinct types of phosphoinositide 3-kinases (PI3K) have been characterized. Unlike other PI3Ks, PI3K class III catalyzes the phosphorylation of phosphatidylinositol at the D3 position, producing phosphatidylinositol-3-phosphate (PIP3) (1). PI3K class III is the mammalian homolog of Vps34, first identified in yeast. PI3K class III interacts with the regular subunit p150, the mammalian homolog of Vps15, which regulates cellular membrane association through myristoylation (2,3). PIP3 recruits several proteins with FYVE or PX domains to membranes regulating vesicular transport and protein sorting (4). Moreover, PI3K class III has been shown to regulate autophagy, trimeric G-protein signaling, and the mTOR nutrient-sensing pathway (5).
Reactivity Human, Mouse, Rat
Tested applications WB IHC
Clonality Polyclonal Antibody
Calculated MW 100 kDa
Recommended Dilutions
WB 1:200-1:2000
IHC 1:50-1:200
Immunogen A recombinant protein of human PIK3C3
Storage Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Synonym VPS34, hVps34
This product is for research use only, not for diagnostic or therapeutic use!

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