| No | Size | Price | Availability | |
| ARP1601-01 | 50ul | 1500.00 | In Stock |  |
| ARP1601-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 1601 |
| Isotype: | IgG | Swiss Prot: | P98082 |
| purity: | Affinity purification |
| Background: |
| This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 82 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
IF 1:50-1:200
|
| Immunogen | A recombinant protein of human DAB2 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | DOC2, DOC-2 |
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