| No | Size | Price | Availability | |
| ARP23644-01 | 50ul | 1500.00 | In Stock |  |
| ARP23644-01 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 23644 |
| Isotype: | IgG | Swiss Prot: | Q6P2E9 |
| purity: | Affinity purification |
| Background: |
| Enhancer of mRNA decapping 4 (EDC4) was originally identified as the autoantigen Ge-1 from a Sj?gren's syndrome patient later diagnosed with primary biliary cirrhosis (1). EDC4 (also known as HEDLS) was later identified as an essential component of cytoplasmic P-bodies responsible for mRNA decapping and degradation (2). Identified EDC4 protein is found as a pair of isoforms generated by alternative splicing and contains several WD domains and a putative nuclear localization signal. EDC4 co-localizes with other P-body decapping proteins such as DCP1A, DCP2 and GW182 (2,3). Experimental evidence suggests that EDC4 may be involved in miRNA-mediated translation repression (4). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB |
| Clonality | Polyclonal Antibody |
| Calculated MW | 152 kDa |
| Recommended Dilutions |
WB 1:500-1:2000
|
| Immunogen | A recombinant protein of human EDC4 |
| Storage | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
| Synonym | GE1, Ge-1, RCD8, HEDL5, HEDLS, RCD-8 |
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