| No | Size | Price | Availability | |
| ARP26353-11 | 50ul | 1500.00 | In Stock |  |
| ARP26353-11 | 100ul | 2000.00 | In Stock | |
| Source: | Rabbit | Gene Id: | 26353 |
| Isotype: | / | Swiss Prot: | Q9UJY1 |
| purity: | Affinity purification |
| Background: |
| HSPB8 (HSP22) is a member of the small heat shock protein superfamily and the human protein is most closely related to HSP27. Similar to most other small HSPs (sHSPs), HSPB8 is predominantly transcribed in skeletal muscle and heart (1). In a two hybrid screen, HSPB8 interacted preferentially with a triple aspartate form of HSP27 which mimics HSP27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type HSP27 (2). HSPB8 has two binding domains (N- and C-terminal) that are specific for different binding partners, and has the ability to bind to itself and other sHSPs such as HSPB7 and HSPB2 (3). The chaperone-like activity is of great importance to the function of HSP22 in various processes including proliferation, apoptosis and macroautophagy (4). |
| Reactivity | Human, Mouse, Rat |
| Tested applications | WB IHC IP IF |
| Clonality | Polyclonal Antibody |
| Calculated MW | 22 kDa |
| Recommended Dilutions |
WB 1:1000
|
| Immunogen | Human HSPB8 |
| Storage | Store at -20°C or lower in antiserum. Avoid freeze/thaw cycles. |
| Synonym | CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22 |
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